Someone who is handicapped has a physical or mental disability that prevents them from living a totally normal life.
I'm going to work two days a week teaching handicapped kids to fish.
我将每周工作两天教残疾儿童钓鱼。
You can refer to people who are handicapped as the handicapped.
measures to prevent discrimination against the handicapped.
防止歧视残疾人的措施。