If something is doomed to happen, or if you are doomed to a particular state, something unpleasant is certain to happen, and you can do nothing to prevent it.
Their plans seemed doomed to failure.
看起来,他们的计划注定要失败。
Someone or something that is doomed is certain to fail or be destroyed.
I used to pour time and energy into projects that were doomed from the start.
过去我总是将时间和精力投入到一些从一开始就注定要失败的项目上。