姓名 ：田红旗

　　性别：男

　　职称：教授

　　学科方向：药物化学

　　招生方向： 药物化学

　　教师简介

　　1990毕业于四川大学化学系获学士学位，1998年毕业于中科院上海有机所获博士学位。1998年至2001年在科罗拉多州立大学做博士后研究， 2001年至2009年在Array BioPharma任高级研究科学家(Senior Research Scientist)，2009年至今被天津国际生物医药联合研究院聘为学术带头人(PI)。研究领域为药物化学和有机化学。药物化学方面，主要是开发新型受体酪氨酸激酶抑制剂(RTK Inhibitor)作为新型抗癌药物的研究，有8年成功的新药研发的实际工作经验，曾将四个化合物推向了从Late Stage Study 到Phase I Study等不同阶段。作为co-inventor，申请有十篇国际专利，是美国癌症研究学会会员(Active Member of AACR)和美国临床癌症研究学会会员(Active-Allied Member of ASCO)。有机化学方面，主要是开展有针对性的新的反应方法学研究，并将这些新的方法应用于非专利药的工艺开发或其它有意义的生物活性分子的合成。在该领域，共发表有14篇国际论文，是美国化学会会员(ACS)，也是美国专业期刊《有机快报》(Organic Letter)和《有机化学杂志》(J. Org. Chem.)的审稿人。

　　发表的文章：

　　1. Structure-activity relationships of SERMs optimized for uterine antagonism and ovarian safety. T. Richardson; S. Frank; M. Wang; C. Clarke; S. Jones; B. Ying; D. Kohlman; O. Wallace; T. Shepherd; R. Dally; A. Palkowitz; A. Geiser; H. Bryant; J. Henck; I. Cohen; D. Rudmann; D. McCann; D. Coutant; S. Oldham; C. Hummel; K. Fong; R. Hinklin; G. Lewis; H. Tian; J. Dodge. Bioorganic & Medicinal Chemistry Letters, 2007, 17(13), 3544-3549.

　　2. A Selective Estrogen Receptor Modulator Designed for the Treatment of Uterine Leiomyoma with Unique Tissue Specificity for Uterus and Ovaries in Rats. C. Hummel; A. Geiser; H. Bryant; I. Cohen; R. Dally; K. Fong; S. Frank; R. Hinklin; S. Jones; G. Lewis; D. McCann; D. Rudmann; T. Shepherd; H. Tian; O. Wallace; M. Wang; Y. Wang; J. Dodge. Journal of Medicinal Chemistry, 2005, 48(22), 6772-6775.

　　3. Asymmetric Strecker Reaction of g-Keto Acids. Facile Entry to a-Substituted and a,g-Disubstituted Glutamic Acids. G. Tang, H. Tian, D. Ma*, Tetrahedron, 2004, 60(46), 10547-10552.

　　4. Asymmetric Synthesis of (S)-1-Aminoindan-1,5-dicarboxylic Acid and Related Analogues via Intramolecular Acylation of Enantiopure α,α-Disubtituted Amino Acids. D. Ma*, D. Ke, H. Tian, B. Wang, D. Cheng, Tetrahedron: Asymmetry, 2002, 13(9), 961-969.

　　5. Designing New Chiral Ketone Catalysts. Enantioselective Epoxidation of cis- and Terminal Olefins, H. Tian, X. She, H. Yu, L. Shu, Y. Shi*, J. Org. Chem., 2002, 67(8), 2435-2446.

　　6. Enantioselective Epoxidation of Terminal Olefins by Chiral Dioxriane, H. Tian, X. She, J. Xu, Y. Shi*, Org. Lett., 2001, 3(12), 1929-1931.

　　7. Electronic Probing of Ketone Catalysts for Asymmetric Epoxidation. Search for More Robust Catalyst, H. Tian, X. She, Y. Shi*, Org. Lett., 2001, 3(5), 715-718.

　　8. Highly Enantioselective Epoxidation of cis-Olefins by Chiral Dioxirane, H. Tian, X. She, L. Shu, H. Yu, Y. Shi*, J. Am. Chem. Soc., 2000, 122, 11551-11552.

　　9. Oxidation of Benzylic Methylene Compounds to Ketones with m- Chloroperoxybenzoic Acid and Oxygen, D. Ma*, C. Xia, H. Tian, Tetrahedron Lett. 1999, 40(50), 8915-8917.

　　10. Enantioselective Syntheses of a-Substituted Glutamic Acids and a, g- Disubstituted Glutamic Acids by an Asymmetric Strecker Reaction, D. Ma*, G. Tang, H. Tian, G. Zou, Tetrahedron Lett. 1999, 40(31), 5753-5756.

　　11. Asymmetric Strecker-Type Reaction of a-Aryl Ketones. Synthesis of s-aM4CPG, s-MPPG, s-AIDA, and s-APICA, the Antagonists of Metabotropic Glutamate Receptors, D. Ma*, H. Tian, G. Zou, J. Org. Chem., 1999, 64(1), 120-125.

　　12. Stereoselective Synthesis of s-MPPG, s-MTPG, and s-(+)-aM4CPG from R-4-Hydroxyphenylglycine, D. Ma*, H. Tian, J. Chem. Soc. Perkin. Transactions I, 1997, 23, 3493-3496.

　　13. Synthesis and Biological Activity of Cyclic Analogues of MPPG and MCPG as Metabotropic Receptor Antagonists, D. Ma*, H. Tian, H. Sun, A. P. Kozikowski, S. Pshenichkin, J. T. Wroblewsk, Biorg. & Med. Chem. Lett., 1997, 7(9), 1195-1198.

　　14. Asymmetric Synthesis of (+)-4CPMG, a Selective Antagonist of Metabotropic Glutamate Receptors, D. Ma*, H. Tian. Tetrahedron: Asymmetry, 1996, 7(6), 1567-1570.

　　发表的专利：

　　1. Preparation of pyrrolidinone and piperidinone derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; M. Chicarelli; C. Gauthier; R. Hinklin; H. Tian; O. Wallace. WO 2006068991.

　　2. Preparation of pyrrolidones and piperidinones as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; M. Chicarelli; C. Gauthier; R. Hinklin; H. Tian; O. Wallace; A. Krasutsky; J. Allen. WO 2006068992.

　　3. Preparation of cycloalkyl lactam derivatives, particularly N-substituted pyrrolidin-2-ones, as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; M. Chicarelli; C. Gauthier; R. Hinklin; H. Tian; O. Wallace; Z. Chen; T. Mabry; J. Mccowan; N. Snyder; L. Winneroski; J. Allen. WO 2006049952.

　　4. Heterobicyclic thiophene compounds as tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; J. DeMeese; J. Gaudino; A. Marlow; J. Seo; A. Thomas; H. Tian. US 2007197537.

　　5. Heterobicyclic pyrazole compounds as Met tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; F. Cohen; J DeMeese; K. Fong; J. Gaudino; T. Kaplan; A. Marlow; J. Seo; A. Thomas; H. Tian; W. Young. WO 2007103308.

　　6. Cyclohexylpyrazole-lactam derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1. T. Aicher; P. Anzeveno; A. Krasutsky; R. Li; T. Mabry; A. Saeed; N. Snyder; G. Stephenson; H. Tian; O. Wallace; L. Winneroski; Y. Xu. WO 2007124254 (Note: this patent had been applied to additional 16 countries besides of the counties designated in WO).

　　7. Preparation of quinoline derivatives as tyrosine kinases inhibitors. J. Gaudino; S. Boyd; A. Marlow; T. Kaplan; K. Fong; J. Seo; H. Tian; J. Blake; K. Koch. WO 2007146824.

　　8. Heterobicyclic Pyrazolopyridine Compounds as tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; F. Cohen; J DeMeese; K. Fong; J. Gaudino; A. Marlow; J. Seo; A. Thomas; H. Tian; W. Young. Had been applied.

　　9. Heterobicyclic Azaindole Compounds as tyrosine kinase inhibitors and their preparation and use. J. Blake; S. Boyd; K. Fong; J. Gaudino; H. Tian. Manuscript in preparation.

　　通讯地址：南开大学药学院 天津市卫津路94号，300071

　　电话：022-23506290

　　传真：022-23507760

　　Email: tianhq@hotmail.com