| 姓 名 | 金英花 | 性 别 | 女 | 出生年月 | 1965-01 |
|---|---|---|---|---|---|
| 所在院校 | 吉林大学 | 所在院系 | 生命科学学院 | ||
| 职称 | 教授 | 招生专业 | 细胞生物学 | ||
| 研究领域 | 细胞内信号转导与抗癌药物的研发 |
| 联系方式 | yhjin@jlu.edu.cn | 电 话 | 0431******* | 邮 编 | 130012 | |
|---|---|---|---|---|---|---|
| 地 址 | 长春市火炬路 1260号吉林大学疫苗研究中心 |
| 个人简介 |
| 主要研究领域 ：Ser/Thr蛋白质激酶在细胞凋亡中的作用机理的研究 主要研究领域 ：细胞内信号转导与抗癌药物的研发 承担科研任务 ：负责国家自然科学基金 1 项“Cyclin A-Cdk2 在细胞凋亡过程中的作用机理的研究” 承担教学任务 ：本科生课程：“高级生物化学 ”，蛋白质与酶 研究生课程：“现代生物化学与分子生物学进展” 社会兼职： 国家留学基金评审专家 参加学术活动情况 ：AACR 91st , 94th, 95thannual meeting等数次国际学术会议并发表了论文。 主要研究领域 ：Ser/Thr蛋白质激酶在细胞凋亡中的作用机理的研究 主要研究领域 ：细胞内信号转导与抗癌药物的研发 承担科研任务 ：负责国家自然科学基金 1 项“Cyclin A-Cdk2 在细胞凋亡过程中的作用机理的研究” 承担教学任务 ：本科生课程：“高级生物化学 ”，蛋白质与酶 研究生课程：“现代生物化学与分子生物学进展” 社会兼职： 国家留学基金评审专家 参加学术活动情况 ：AACR 91st , 94th, 95thannual meeting等数次国际学术会议并发表了论文。 |
| 著作及论文 |
| 1. Ying Hua Jin, Kye Jin Yoo, You Hui Lee, and Seung Ki Lee. Caspase 3-mediated Cleavage of p21WAF1/CIP1 Associated with the Cyclin A-Cdk2 Complex is a Prerequisite for Apoptosis in SK-HEP-1 Cells. J Biol Chem. 2000, 275 30256-30263. 2. Hyungshin Yim, Ying Hua Jin, Byoung Duck Park, Hye Jin Choi, Seung Ki Lee Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49 truncated Cdc6 and apoptosis. Mol Biol. Cell 2003, 14, 4250-4259. 3. Ying Hua Jin, JoonSeoK Choi , Jeong Hill Park , and Seung Ki Lee. Panaxadiol, a new Diol-Type Ginseng Saponin, Induces Cell Cycle Arrest at S phase by Selective Inhibition of Cyclin A-Associated Cdk2 Activity. Carcinogenesis 2003, 24, 1767-1772. 4. Ying Hua Jin, Hyungshin Yim, Jeong Hill Park , and Seung Ki Lee*. Cdk2activity is associated with depolarization of mitochondrial membrane potentialduring apoptosis. Biochem Biophys Res Commun. 2003, 305, 974-80 5. Han X Q,Mark,Bartlam, Jin Y H, and Rao, Z, The expression of SARS-CoV M gene in P. Pastoris and diagnosticutility of expressed product. Journal of Virological Methods. 2004,122, 105-111 6. Ham YM, Choi KJ, Song SY, Jin YH, Chun MW, Lee SK. Xylocydine, a novel inhibitor of cyclin-dependent kinases, prevents the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic cell death of SK-HEP-1 cells J Pharmacol Exp Ther. 2004, 308, 814-9. 7. Young Joo Lee, Won Chung Lim, Ying Hua Jin, and Seung Ki Lee. Effects of Estrogen Receptor and Estrogen on The Chromatin Structure in Estrogen Receptor Stably Transfected Cells. Exp Mol Med. 2002, 34 95-9. 8. Seung-Ki Lee, Ying Hua Jin, and Y... 1. Ying Hua Jin, Kye Jin Yoo, You Hui Lee, and Seung Ki Lee. Caspase 3-mediated Cleavage of p21WAF1/CIP1 Associated with the Cyclin A-Cdk2 Complex is a Prerequisite for Apoptosis in SK-HEP-1 Cells. J Biol Chem. 2000, 275 30256-30263. 2. Hyungshin Yim, Ying Hua Jin, Byoung Duck Park, Hye Jin Choi, Seung Ki Lee Caspase-3-mediated cleavage of Cdc6 induces nuclear localization of p49 truncated Cdc6 and apoptosis. Mol Biol. Cell 2003, 14, 4250-4259. 3. Ying Hua Jin, JoonSeoK Choi , Jeong Hill Park , and Seung Ki Lee. Panaxadiol, a new Diol-Type Ginseng Saponin, Induces Cell Cycle Arrest at S phase by Selective Inhibition of Cyclin A-Associated Cdk2 Activity. Carcinogenesis 2003, 24, 1767-1772. 4. Ying Hua Jin, Hyungshin Yim, Jeong Hill Park , and Seung Ki Lee*. Cdk2activity is associated with depolarization of mitochondrial membrane potentialduring apoptosis. Biochem Biophys Res Commun. 2003, 305, 974-80 5. Han X Q,Mark,Bartlam, Jin Y H, and Rao, Z, The expression of SARS-CoV M gene in P. Pastoris and diagnosticutility of expressed product. Journal of Virological Methods. 2004,122, 105-111 6. Ham YM, Choi KJ, Song SY, Jin YH, Chun MW, Lee SK. Xylocydine, a novel inhibitor of cyclin-dependent kinases, prevents the tumor necrosis factor-related apoptosis-inducing ligand-induced apoptotic cell death of SK-HEP-1 cells J Pharmacol Exp Ther. 2004, 308, 814-9. 7. Young Joo Lee, Won Chung Lim, Ying Hua Jin, and Seung Ki Lee. Effects of Estrogen Receptor and Estrogen on The Chromatin Structure in Estrogen Receptor Stably Transfected Cells. Exp Mol Med. 2002, 34 95-9. 8. Seung-Ki Lee, Ying Hua Jin, and You Hui Lee, Caspase 3-mediated Cleavage of p21WAF1/CIP1 Associated with the Cyclin A-Cdk2 Complex is a Prerequisite Process for Apoptotic Progression in SK-HEP-1 Cells. 91st annual meeting, April 1-5, 2000, #993, San Francisco, CA 9. Jin YH, Lee SJ, Chung MH, Park JH, Park YI, Cho TH, Lee SK. Aloesin and Arbutin Inhibit Tyrosinase Activity in a Synergistic Manner via a Different Action Mechanism. Arch Pharm Res. 1999, 22, 232-236. 10. Hyungshin Yim1, In Sun Hwang1, Joon Seok Choi1, Kwang-Hoon Chun1, Ying Hua Jin2, Young-Mi Ham1, Kwang Youl Lee3, and Seung Ki Lee*1 Cleavage of Cdc6 by caspase-3 promotes ATM/ATR kinase-mediated apoptosis of HeLa cells, Journal of Cell Biology Accepted Patents 1．SARS coronavirus spike protein fragment eliciting a strong immune response the coding sequence and its applicants (03153606.9). 2．A protein expression vector based on the cleavage site of coronavirus main protease and its application (20041009714.6) |