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第一部分:个人情况介绍、概览
池岛乔,男,博士,外籍教授,博士生导师。1972年毕业于日本东北大学,获理学部生物学科学士学位,1974年于同校获理学研究科硕士学位,1978年获日本东北大学理学研究科博士学位。曾在日本横滨市立大学医学部、美国哈佛大学医学部、Tufts大学医学部任教,此后在日本万有制药株式会社(美国Merck公司的分公司)分子生物学研究所担任部长。1996年来到中国,在长春中医药大学担任教授,于2002年开始在沈阳药科大学任教。在沈阳药科大学从事免疫药理学工作10余年来(2002年-),共发表相关论文186篇(其中SCI收录143篇),学会发表论文97篇(其中国际学会80篇)。迄今共培养博士研究生40名、硕士研究生49名,本科专题生约90名。
第二部分:担任学术职务、社会兼职、人才称号以及个人获奖
1.日本临床中医药学会理事;
2.日本未病系统学会评议人;
3.辽宁中医学院客座教授;
4.广州中医药大学客座教授;
5.哈尔滨医科大学顾问教授;
6.1997年获得长春市白求恩医学工作者;
7.1999年获得吉林省优秀外国专家;
8.2002年获得沈阳市玫瑰奖(优秀外国专家);
9.2003年获得辽宁省友谊奖(优秀外国专家);
10.2012年沈阳高校优秀研究生导师;
11.2013年度沈阳药科大学“教书育人”优秀研究生导师。
第三部分:主持、参与的科研项目(含科研获奖等情况)
1. 水飞蓟宾对阿尔兹海默症以及衰老过程中活性氧/活性氮-线粒体-自噬-炎症小体途径调控作用机制研究,国家自然科学基金面上项目,基金编号81273517(负责人)
2. IMPDH为靶点的小分子抑制剂的设计、合成及活性研究,国家自然科学基金,基金编号21372157(第二参与人)
3. 肿瘤细胞与心肌细胞自噬调节剂的筛选,辽宁省教育创新团队项目,项目编号2009T094(参与人)
第四部分:近年来发表代表性论文或论著 (需标明是否第一作者或通讯作者,SCI须写明影响因子):
2013-2014(2年间SCI论文发表情况):
1. Weiwei Liu, Wuxiyar Otkur, Lingzhi Li, Qiong Wang, Hao He, Linghe Zang, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Mingyu Xia, Takashi Ikejima*. Interference of silibinin with IGF-1R signalling pathways protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis. Biochemical and Biophysical Research Communication (BBRC), 432 (2):314-319, 2013. (IF:2.281)
2. Qiong Wang, Weiwei Liu, Hong Zeng, Xuqin Xie, Guangxi Ye, Shin-ichi Tashiro, Satoshi Onodera, Shan Jiang, Takashi Ikejima*. p53-mediated autophagy adjustment as involved in the protection of silibinin against murine dermal inflammation and epidermal apoptosis induced by UVB irradiation. Journal of Asian Natural Products Research, 15 (2):117-129, 2013.(IF:0.968)
3. Qi M, Fan S, Yao G, Li Z, Zhou H, Tashiro SI, Onodera S, Xia M, Takashi Ikejima*. Pseudolaric Acid B-Induced Autophagy Contributes to Senescence via Enhancement of ROS Generation and Mitochondrial Dysfunction in Murine Fibrosarcoma L929 Cells. J Pharmacol Sci. 121 (3):200-211, 2013. (IF:2.114)
4. Linghe Zang, Hao He, Yang Yu, Qian Xu, Weiwei Liu, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Reactive oxygen species H2O2 and •OH(-) promotes oridonin-induced phagocytosis of apoptotic cells by human histocytic lymphoma U937 cells. Int Immunopharmacol. 15 (2):414-423, 2013. (IF:2.711)
5. Li F, Sun Q, Hong L, Li L, Wu Y, Xia M, Ikejima T, Peng Y, Song S. Daphnane-type diterpenes with inhibitory activities against human cancer cell lines from Daphne genkwa. Bioorg Med Chem Lett. 23 (9):2500-2504, 2013. (IF:2.331)
6. Liu W, Otkur W, Li L, Wang Q, He H, Ye Y, Zhang Y, Hayashi T, Tashiro SI, Onodera S, Ikejima T*. Autophagy induced by silibinin protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis. J Photochem Photobiol B, 123:23-31, 2013. (IF:2.803)
7. He, Hao; Zang, Linghe; Feng, Yongsheng; Wang, Jian; Liu, Weiwei; Chen, LiXia; Kang, Ning; Tashiro, Shin-ichi; Onodera, Satoshi; Qiu, Feng; Takashi Ikejima*. Physalin A Induces Apoptotic Cell Death and Protective Autophagy in HT1080 Human Fibrosarcoma Cells. Journal of Natural Products, 76:880-888, 2013. (IF:3.947)
8. Hao He, Linghe Zang, Yongsheng Feng, LiXia Chen, Ning Kang, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu, Takashi Ikejima*,. Physalin A Induces Apoptosisvia p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-B survival pathway in A375-S2 cells. Journal of Ethnopharmacology, Epub 148:544-555, 2013. (IF:2.939)
9. Min Qi, Haiyan Zhou, Simiao Fan, Zhao Li, Guodong Yao, Shin-ichi Tashiro, Satoshi Onodera, Mingyu Xia and Takashi Ikejima*. mTOR inactivation by ROS-JNK-p53 pathway plays an essential role in Pseudolaric acid B induced autophagy-dependent senescence in murine fibrosarcoma L929 cells. Eur. J Pharmacol. 715:76-88, 2013. (IF:2.684)
10. Weiwei Liu, Wuxiyar Otkur, Yuning Zhang, Qiuyuan Li, Yuanchao Ye, Linghe Zang, Hao He, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Silibinin protects murine fibroblast L929 cells from UVB-induced apoptosis through the simultaneous inhibition of ATM-p53 pathway and autophagy. FEBS J, 280:4572-4584, 2013. (IF:3.986)
11. Huang XX, Zhou CC, Li LZ, Li FF, Lou LL, Li DM, Ikejima T, Peng Y, Song SJ. The cytotoxicity of 8-O-4' neolignans from the seeds of Crataegus pinnatifida. Bioorg Med Chem Lett. Epub 23:5599-5604, 2013. (IF:2.331)
12. Huang XX, Zhou CC, Li LZ, Peng Y, Lou LL, Liu S, Li DM, Ikejima T, Song SJ. Cytotoxic and antioxidant dihydrobenzofuran neolignans from the seeds of Crataegus Pinnatifida. Fitoterapia, 91:217-223, 2013. (IF:2.216)
13. Liu, Ying; Liu, Jian-Hong; Chai, Kuan; Tashiro, Shin-Ichi; Onodera, Satoshi; Ikejima, Takashi*. Inhibition of c-Met promoted apoptosis, autophagy and loss of the mitochondrial transmembrane potential in oridonin-induced A549 lung cancer cells. Journal of Pharmacy and Pharmacology, 65:1622-1642, 2013. (IF:2.161)
14.Yuan-Chao Ye, Hong-Ju Wang, Ling Chen, Wei-Wei Liu, Shin-Ichi Tashiro, Satoshi Onodera, Ming-Yu Xia, Takashi Ikejima*. Negatively-regulated necroptosis by autophagy required caspase-6 activation in TNFα-treated murine fibrosarcoma L929 cells. Int Immunopharmacol. 17:548-555, 2013. (IF:2.711)
Guodong Yao, Min Qi, Xiaoling Ji, Simiao Fan, Lei Xu, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejima*. Pseudolaric Acid B induced protective G2/M arrest and apoptotic cell death in human cervical carcinoma HeLa cells. Arch Biochem Biophys, 558:51-60, 2014. (IF:3.043)
15.Hao He, Yong-Sheng Feng, Ling-He Zang, Wei-Wei Liu, Li-Qin Ding, Li-Xia Chen, Ning Kang, Toshihiko Hayashi, Shin-ichi Tashiro, Satoshi Onodera, Feng Qiu, Takashi Ikejima*. Nitric Oxide Induces Apoptosis and Autophagy; Autophagy Down-regulates NO Synthesis in Physalin A-treated A375-S2 Human Melanoma Cells. Food and Chemical Toxicology, 71:128-135, 2014. (IF:2.61)
16.Yin Y, Zhao XC, Wang SJ, Gao PY, Li LZ, Ikejima T, Song SJ.
Synthesis and biological evaluation of novel sarsasapogenin derivatives as potential anti-tumor agents. Steroids 93C:25-31, 2014.(IF: 2.716)
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