毛世瑞，沈阳药科大学药剂教研室教授，德国理学博士，博士生/硕士生导师。国家双语教学示范课程-药剂学课程负责人。

简历：

1987-1991 沈阳药科大学 获理学学士学位

1991-1994 沈阳药科大学 获药剂学硕士学位

1994-     沈阳药科大学药学院药剂教研室助教、讲师、副教授、教授

2002-2004 德国马尔堡大学 获理学博士学位

2005-2006 德国马尔堡大学 博士后研究

社会兼职：

亚洲药物制剂科学杂志（Asian Journal of Pharmaceutical Sciences）主编助理

国际缓控释协会(CRS) 高级会员 (Fellow of CRS)

The Scientific World Journal 编委

中国颗粒学会颗粒制备与处理专业委员会 委员

国内外30余个杂志的特约审稿人

主要研究方向：

1.生物可降解高分子聚合物作为药物载体的研究

2.粘膜给药系统（鼻、肺、眼等）的研究

3.微纳米给药系统的研究

主要科研项目：

1.国家自然科学基金课题“基于多功能自组装聚合物纳米胶束的口服传递系统的构建及其性能研究”，项目负责人, 2013.1-2016.12.

2.国家科技部中泰合作项目“聚合物纳米复合物的结构特性与大分子药物胃肠吸收”, 项目负责人, 2011.1-2013.6

3.中德国际合作项目“肺部给药系统研究”，项目负责人, 2012.1-2014.12

4.中美国际合作项目“应用纳米技术提高难溶性药物的生物利用度”，项目负责人, 2009.11-2011.10

5.国家中医药管理局回国留学人员科技活动择优资助课题, “长效注射PLGA微球的释药特性和影响药物体内分布的因素”, 项目负责人，2008.3-2010.2

6.国家教育部回国人员科研启动基金，“低分子肝素/壳聚糖及其衍生物的纳米复合物口服吸收”， 项目负责人，2008.2-2010.2

7.参与国家科技部973重大科学研究计划项目“纳米技术改善难溶性药物功效的应用基础研究”（2009CB903302）, 学术骨干，2009. 1—2013. 1.

8.沈阳药科大学回国基金课题“胰岛素壳聚糖纳米复合物的研究”，项目负责人，2006-2007

9.国家双语教学示范课程-药剂学建设项目国家双语教学示范课程-药剂学建设项目, 项目负责人，2010-

主要获奖和成果：

1.国际缓控释学会（CRS）特别会员（Fellow of CRS）:奖励给在药物传输科学技术领域有突出贡献者（2010）

2.获得由国际缓控释协会授予的CRS-Nagai Postdoctoral Research Achievement Award， 2009.

3.Journal of controlled release 十大审稿人(top reviewer) (2006,2007,2008)

4.辽宁省自然科学学术成果一等奖（2012）: New strategies to improve the intranasal absorption of insulin.

5.辽宁省自然科学学术成果一等奖（2011）: Chitosan-based formulations for delivery of DNA and siRNA Chitosan-based formulations for delivery of DNA and siRNA.

6.辽宁省自然科学学术成果一等奖（2010）: Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats.

7.辽宁省百千万人才千人层次, 2009

8.2009年度ISP-沈阳药科大学Hulmut Award.

9.2007-2008年度沈阳药科大学优秀教师

10.沈阳药科大学优秀硕士毕业论文指导教师 (2008, 2009，2010年度)

11.沈阳药科大学优秀本科毕业论文指导教师 (2007,2008, 2009，2011年度)

12.2002-2004年度德意志学术交流中心(DAAD)奖学金

代表性著作：

1.学术专著“CHITOSAN COPOLYMERS FOR INTRANASAL DELIVERY OF INSULIN”, Der ander Verlag, Germany, 2004. 11.

2.Delivery Technologies for Biopharmaceuticals: Peptides, Proteins, Nucleic Acids and Vaccines. John Wiley Press. 2009. 编者, 第三章

3.药剂学实验讲义（英文版）沈阳药科大学 2009.2. 主编

4.《经皮给药新剂型》人民卫生出版社 2006.12. 编者

5.《药物粉体压缩技术》化学工业出版社2008.4. 译者

6.面向21世纪课程教材《药剂学》，中国医药科技出版 2002. 8，编者

7.国家执业药师资格考试《药学综合知识与技能过关全攻略》， 辽宁科学技术出版社，2008.3，主编

8. 国家执业药师资格考试《全真模拟试题西药部分》辽宁科学技术出版社，2008.3, 副主编

9.《药剂学实验指导》，人民卫生出版社 2011. 参编

10.《药剂学应试指南与习题解析》，中国医药科技出版社 2011. 参编

代表性论文:

已在国内外学术期刊发表研究论文70余篇，其中SCI收载31篇, 被引用1000余次。代表性论文如下：

1.Mao Shirui, Guo Chunqiang, Shi Yi, Li Luk Chiu.Recent advances in polymeric microspheres for parenteral drug delivery-part 2. Expert Opin Drug Deliv. 2012 Aug 28. [Epub ahead of print]

2.Mao Shirui, Guo Chunqiang, Shi Yi, Li Luk Chiu. Recent advances in polymeric microspheres for parenteral drug delivery - part 1. Expert Opin Drug Deliv. 2012 Sep;9(9):1161-76. Epub 2012 Jul 27.

3.Tian Ye, Mao Shirui＊. Amphiphilic polymeric micelles as the nano-carrier for the peroral delivery of poorly soluble anticancer drugs. Expert Opinion on Drug Delivery 2012, 9(6)， 687-700

4.Sun Wei, Tian Wei, Zhang Yuyang, He Jianyong, Mao Shirui ＊, Fang Liang. Effect of novel stabilizers—cationic polymers on the particle size and physical stability of poorly soluble drug nanocrystals. Nanomedicine: NBM. 2012, 8(4), 460-467.

5.Mao Shirui＊, Zhang Tingting, Sun Wei, Ren Xuhong. The Depolymerization of Sodium Alginate by Oxidative Degradation. Pharm Dev Tech 2011, in press

6.Sun Wei, Mao Shirui ＊, Shi Yi, Li Chiu Luk, Fang Liang. Nanonization of Itraconazole by High Pressure Homogenization: Stabilizer Optimization and Effect of Particle Size on Oral Absorption. Journal of Pharmaceutical Sciences, 2011,100, 3365-3373

7.毛世瑞＊ 田野 王琳琳. 药物纳米载体-聚合物胶束的研究进展. 沈阳药科大学学报， 2010,27(12), 979-986.

8.王彦君，毛世瑞＊，孙伟, 王娟，那立东，张婷婷. 白藜芦醇PLGA长效注射微球的制备及影响因素研究. 沈阳药科大学学报 2010, 27(4), 265-272.

9.Na Lidong, Mao Shirui＊, Wang Juan, Sun Wei. Comparison of different absorption enhancers on the intranasal absorption of isosorbide dinitrate in rats. Int J Pharm 2010, 397(1-2), 59-66.

10.Duan Xiaopin, Mao Shirui＊. New strategies to improve the intranasal absorption of insulin. Drug Discovery Today, 2010, 15(11-12), 416-427.

11.Zhang Tingting, Mao Shirui＊, Sun Wei. Design and in vitro evaluation of a film-controlled dosage form self-converted from monolithic tablet in gastrointestinal environment. Journal of Pharmaceutical Sciences, 2010, 99(11), 4678-4690.

12.Sun Wei, Mao Shirui＊, Wang Yanjun, Junyaprasert VB, Zhang Tingting, Na Lidong, Wang Juan. Bioadhesion and oral absorption of enoxaparin nanocomplexes. Int J Pharm 2010, 386, 275-281.

13.Mao Shirui＊, Sun Wei, Kissel T. Chitosan based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev 2010，62(1)，12-27.

14.Zhao Ruizhi, Liu Shaojun, Mao Shirui, Wang Yanjun. Study on liver targeting effect of vinegar-baked Radix Bupleuri on resveratrol in mice. Journal of ethnopharmology, 2009, 126,415-420

15.Mei Dan, Mao Shirui＊, Sun Wei, Kissel T. Effect of chitosan structure properties and molecular weight on the intranasal absorption of tetramethylpyrazine phosphate in rats. Eur J Pharm Biopharm. 2008, 70(3), 874-881.

16.Sun Wei, Mao Shirui＊, Mei Dan and Kissel T. Self-Assembled Polyelectrolyte Nanocomplexes between Chitosan Derivatives and Enoxaparin. Eur J Pharm Biopharm. 2008 ,69(2),417-425.

17.Mao Shirui, Shi Y, Li L, Xu J, Schaper A, Kissel T. Effects of process and formulation parameters on characteristics and internal morphology of poly(d,l-lactide-co-glycolide) microspheres formed by the solvent evaporation method. Eur J Pharm Biopharm. 2008，68，214-223.

18.Germershaus O, Mao Shirui, Sitterberg J, Bakowsky U, Kissel T. Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: Establishment of structure-activity relationships in vitro. J Control Release 2008，125(2):145-154.

19.Jintapattanakit A., Mao Shirui, Kissel T., V. B. Junyaprasert. Physicochemical Properties and Biocompatibility of N-Trimethyl Chitosan: Effect of Quaternization and Dimethylation. Eur. J. Pharm.Biopharm, 2008 Oct;70(2):563-571.

20.梅丹，毛世瑞＊. 环糊精及其衍生物对磷酸川芎嗪鼻黏膜吸收的促进作用. 沈阳药科大学学报 2008，25（12），933-938.

21.Mao Shirui, Xu Jing, Cai Cuifang, Germershaus Oliver, Schaper Andreas, Kissel Thomas. Effect of WOW process parameters on  morphology of FITC-dextran loaded PLGA microspheres. Int. J. Pharm. 2007,334, 137-148.

22.Mao Shirui, Augsten C, Maeder K, Kissel. T.Characterization of chitosan and its derivatives using asymmetrical flow field-flow-fractionation: A comparison with traditional methods. J Pharm Biomed Anal 2007, 45(5),736-741.

23.Mao Shirui, Neu M., Germershaus O., Merkel O., Sitterberg J., Bakowsky U., and Kissel T. Influence of Polyethylene Glycol Chain Length on the Physicochemical and Biological Properties of Poly(ethylene imine)-graft-Poly(ethylene glycol) Block Copolymer/SiRNA Polyplexes. Bioconjugate Chem., 2006，17 (5), 1209 -1218.

24.Mao Shirui, Bakowsky U., Jintapattanakit A., Kissel T. Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin. J Pharm Sci 2006, 95(5), 1036-1048

25.Mao Shirui, Yang Shiling, Bi Dianzhou. Pharmacodynamics and potential toxicity of intranasally administrated dipyrone. Biol. Pharm. Bull 2006，29(7), 1355-1359.

26.Mao Shirui, Shuai Xintao, Unger F., Wittmar M., Xie Xiulan and Kissel T. Synthesis, characterization and cytotoxicity of poly (ethylene glycol)-graft-trimethyl chitosan block copolymers. Biomaterials. 2005, 26(32),6343-6356.

27.Mao Shirui, Germershaus O., Fischer D., Linn T., Schnepf R., Kissel T. Uptake and transport of self-assembled PEGylated trimethyl chitosan block copolymer-insulin nanocomplexes in Caco-2 cell monolayers. Pharm. Res. 2005, 22(12), 2058-2068.

28.Mao Shirui, Wang Pu, Bi Dianzhou. Investigations on 5-Fu solid lipid nanoparticles prepared by hot homogenization. Die Pharmazie 2005, 60(4), 273-277.

29.Mao Shirui, Shuai Xintao, Unger Florian, Simon Michael, Bi Dianzhou, and Kissel Thomas. The depolymerization of chitosan: Effects on physicochemical and biological properties, Int J Pharm 2004, 281, 45-54.

30.Mao Shirui, Chen Jianming, Liu Huan, Wei Zhenping, Bi Dianzhou. Intranasal administration of melatonin starch microsphere, Int J Pharm, 2004, 272(1-2), 37-43.

31.毛世瑞, 李茗, 毕殿洲. 硫酸沙丁胺醇油包水型口服纳米乳的制备及小肠吸收考察. 沈阳药科大学学报, 2005,22(6), 401-404.

32.毛世瑞, 刘欢, 陈建明, 魏振平, 毕殿洲. 褪黑激素鼻腔给药淀粉微球的制备工艺.沈阳药科大学学报, 2004, 21(5),324-327.

33.毛世瑞, 纪宏宇, 毕殿洲. 微乳化技术制备固体脂质纳米粒. 药学学报, 2003, 38(8), 624-626.