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徐进宜：药学博士，教授，博导，中国药科大学药学院药物化学教研室副主任。
研究方向：新药分子设计与合成研究(硕士);化学创新药物合成与评价研究(博士)。
1986年毕业于中国药科大学，留校任教27年，一直工作在教学科研第一线，先后讲授了药物化学、药物合成反应、药物分子设计、药学英语、专业英语等课程。协助指导和独立指导过博士、硕士研究生40余名，在国内外期刊发表论文100余篇，其中SCI论文60余篇;申请国内外发明专利20余项，参编著作10部。曾获“教书育人”优秀教师奖;国家科技部优秀论文二等奖;中国药科大学先进科技工作者等荣誉。
担任国家863计划评审专家、国家自然科学基金评审专家和农业部兽药审评专家;担任JournalofMedicinalChemistry,CurrentMedicinalChemistry，EuropeanJournalofMedicinalChemistry,Bioorganic&MedicinalChemistry等国际药物化学杂志特约审稿人。
研究经历包括：23-羟基白桦酸的结构改造、生物活性与构效关系研究;喜树碱类分子结构修饰与生物活性研究;天然活性产物XJP全合成及其类似物的设计合成研究;冬凌草甲素的结构修饰与生物活性研究;四环二萜类活性天然产物化合物库的构建、生物学评价及作用机制研究;非肽类血管紧张素II受体拮抗剂的设计与合成研究;AT1受体拮抗剂类新药氯沙坦、依贝沙坦、坎地沙坦的合成工艺研究;血管紧张素AT1受体和内皮素ETA受体双重拮抗剂研究;新型抗高血压药物及抗心衰药物ATPT的研究;选择性环氧化酶II抑制剂的研究;非苯二氮卓类GABAA受体激动剂的研究;COX-2/5-LOX双重抑制剂的研究;手性Ocotillol型人参皂苷结构修饰衍生物的设计与合成研究;在日本近畿大学完成了天然活性产物GregatinB的全合成及结构修饰研究。
负责承担了十一五“重大新药创制”、国家自然科学基金、国家科技支撑计划、教育部科学技术研究重点项目、高等学校博士学科点专项科研基金、长三角科技攻关、江苏省自然科学基金、江苏省医药科技攻关等国家和省部级项目的研究。
近期代表性SCI论文(总影响因子大于70)，均为通讯作者。
(1)JieLiu,HaoRen,JinyiXu*,RenrenBai,QiYan,WenlongHuang,XiaomingWu*,JihuaFu,QiujuanWang,QianWu,RongFu.Totalsynthesisandantihypertensiveactivityof7,8-dihydroxy-3-methyl-isochromanone-4.Bioorg.&Med.Chem.Lett.,2009,19:1822-1824.(IF2.661)
(2)PeiqingZhu,YiBi,JinyiXu*,ZanLi,JunLiu,LuyongZhang,WencaiYe,XiaomingWu*.Terpenoids.III:Synthesisandbiologicalevaluationof23-hydroxybetulinicacidderivativesasnovelinhibitorsofglycogenphosphorylase.Bioorg.&Med.Chem.Lett.,2009,19:6966–6969.(IF2.661)
(3)BoJiang,YiZeng,JinyiXu*,YongnaZhang,QiujuanWang,NiyueSun,TaoLu,andXiaomingWu.Design,Synthesis,andBiologicalEvaluationof1,5-Diarylsubstitued-1,2,4-triazoleDerivativesasSelectiveCyclooxygenase-2Inhibitors.ArchivderPharmazie,2010,9:500-508.(IF1.708)
(4)YiyunWang,ZiyuanLi,YueHuang,ChanghuaTang,XiaomingWu,JinyiXu*,HequanYao*.Copper(II)-catalyzedoxidationof4-carboxythiazolinesand4-carboxyoxazolinesto4-carboxythiazolesand4-carboxyoxazoles.Tetrahedron.2011,67,7406-7411.(IF3.025)
(5)ShangLi,HequanYao,JinyiXu*,ShengJiang*.SyntheticRoutesandBiologicalEvaluationofLargazoleandItsAnaloguesasPotentHistoneDeacetylaseInhibitors.Molecules.2011,16,4681-4694.(IF2.386)
(6)LeiWang,DahongLi,YihuaZhang*,JinyiXu*.Recentprogressinthedevelopmentofnaturalent-kauranediterpenoidswithanti-tumoractivity.Mini-Rev.Med.Chem.2011,11,910-919.(IF2.528)
(7)ChaoLeiWang,Bing-FengSun*,Shu-GuangChen,RuiDing,Guo-QiangLin*,Jin-yiXu*,Yong-JiaShang.ConciseFormalSynthesisof(+)-EnglerinAandTotalSynthesisof(–)-OrientalolF:EstablishmentoftheStereochemistryoftheOrganocatalytic[4+3]-CycloadditionReaction.Synlett,2012,23,263–266.(IF2.710)
(8)DahongLi,LeiWang,HaoCai,YihuaZhang*,JinyiXu*.Synthesisandbiologicalevaluationofnovelfurozan-basednitricoxide-releasingderivativesoforidoninaspotentialanti-tumoragents.Molecules,2012,17,7556-7568.(IF2.386)
(9)FeiSun,PeiqingZhu,HequanYao,XiaomingWu*,JinyiXu*.Apartialsynthesisof23-hydroxybetulonicacidand23-hydroxybetulinicacidstartingfrombetulinicacid.J.Chem.Res.,2012,36(5):254-257.(IF0.921)
(10)YiBi,JinyiXu*,FeiSun,XiaomingWu*,WencaiYe,YijunSunandWenwenHuang.Synthesisandbiologicalactivityof23-hydroxybetulinicacidC-28esterderivativesasantitumoragentcandidates.Molecules,2012,17(8):8832-8841.(IF2.386)
(11)RenrenBai,XueYang,YaoZhu,ZhiwenZhou,WeijiaXie,HequanYao,JieyunJiang,JieLiu*,MingqinShen,XiaomingWu,JinyiXu*.Novelnitricoxide-releasingisochroman-4-onederivatives:Synthesisandevaluationofantihypertensiveactivity.Bioorg.&Med.Chem.,2012,20(23):6848-6855.(IF2.921)
(12)RenrenBai,ZhenWei,JieLiu,WeijiaXie,HequanYao,XiaomingWu*,JieyunJiang,QiujuanWangandJinyiXu*.Synthesisandbiologicalevaluationof4′-[(benzimidazole-1-yl)methyl]biphenyl-2-sulfonamidederivativesasdualangiotensinII/endothelinAreceptorantagonists.Bioorg.&Med.Chem.,2012,20(15):4661-4667.(IF2.921)
(13)RenrenBai,JieLiu,YaoZhu,XueYang,ChenYang,LingyiKong,XiaobingWang,HengyuanZhang,HequanYao,MingqinShen,XiaomingWu*,JinyiXu*.Chiralseparation,configurationalidentificationandantihypertensiveevaluationof(±)-7,8-dihydroxy-3-methyl-isochromanone-4.Bioorg.&Med.Chem.Lett.,2012,22(20),6490-6493.(IF2.661)
(14)LeiWang,DahongLi,ShengtaoXu,HequanYao,YihuaZhang*,JieyunJiang,JinyiXu*.Theconversionoforidonintospirolactone-typeorenmein-typediterpenoid:synthesisandbiologicalevaluationofent-6,7-seco-oridoninderivativesasnovelpotentialanticanceragents.Eur.J.Med.Chem.2012,52,242-250.(IF3.499)
(15)XiaoliWang,QianZhao,XuliangWang,TingtingLi,YishengLai,SixunPeng,HuiJi,JinyiXu*andYihuaZhang*.StudiesontheenantiomersofZJM-289:synthesisandbiologicalevaluationofantiplatelet,antithromboticandneuroprotectiveactivities.Organic&BiomolecularChemistry,2012,10(45):9030-9040.(IF3.696)
(16)DahongLi,HaoCai,BowenJiang,GuyueLiu,YuetongWang,LeiWang,HequanYao,XiaomingWu*,YijunSun,JinyiXu*.Synthesisofspirolactone-typediterpenoidderivativesfromkaurene-typeoridoninwithimprovedantiproliferativeeffectsandtheirapoptosis-inducingactivityinhumanhepatomaBel-7402cells.Eur.J.Med.Chem.2013,59,322-328.(IF3.499)
(17)XiaoliWang,LinnaWang,ZhangjianHuang,TingtingLi,HuiJi,JinyiXu*,YihuaZhang*.Synthesisandbiologicalevaluationofnitricoxidereleasingderivativesof6-amino-3-n-butylphthalideaspotentialantiplateletagents.BioorgMedChemLett,2013,1985-1988.(IF2.921)
(18)RenrenBai,XueYang,WenHong,YiqunTang,HequanYao,JieyunJiang,JieLiu,MingqinShen,XiaomingWu*,JinyiXu*.Novelhybridsofnaturalisochroman-4-onebearingN-substitutedisopropanolamineaspotentialantihypertensivecandidates.Bioorg.&Med.Chem.,2013,21:2495-2502.(IF2.921)
(19)ShengtaoXu,YuZhou,JinyiXu*,HualiangJiang,HongLiu*.Gold-catalyzedMichaelAddition/IntramolecularAnnulationCascade:anEffectivePathwayfortheChemoselectiveandRegioselectiveSynthesisofTetracyclicIndoleDerivativesinWater.GreenChem.,2013,15,718-726.(IF6.320)
(20)YiBi,FeiSun,XiaomingWu*,WencaiYe,YijunSunandWenwenHuang,JinyiXu*.SynthesisandBiologicalActivityof28-AmideDerivativesof23-HydroxyBetulinicAcidasAntitumorAgentCandidates.MedicinalChemistry,2013,9,920-925.(IF1.496)
(21)XiaoliWang,LinnaWang,TingtingLi,ZhangjianHuang,YishengLai,HuiJi,XiaolongWan,JinyiXu*,YihuaZhang*.NovelHybridsofOpticallyActiveRing-Opening3-n-ButylphthalideDerivativeandIsosorbideasPotentialAnti-IschemicStrokeAgents.JMed.Chem.,2013,56,3078-3089.(IF5.614)
(22)DahongLi,ShengtaoXu,HaoCai,LinglingPei,LeiWang,HequanYao,XiaomingWu*,JieyunJiang,YijunSun,JinyiXu*.Libraryconstructionandbiologicalevaluationofnovelenmein-typediterpenoidanalogsaspotentialanticanceragents.Chem.Med.Chem.,2013,8:812-818.(IF3.151)
(23)DahongLi,ShengtaoXu,HaoCai,LinglingPei,HengyuanZhang,LeiWang,HequanYao,XiaomingWu*,JieyunJiang,YijunSun,JinyiXu*.Enmein-typediterpenoidanalogsfromnaturalkaurene-typeoridonin:synthesisandtheirantitumorbiologicalevaluationEur.J.Med.Chem.2013,64,215-221.(IF3.499)
(24)ZiwenZhou,CongMa,HengyuanZhang,YBi,XiaChen,HuaTian,XiaoniXie,QingguoMeng,PeterJohnLewis*,JinyiXu*.SynthesisandBiologicalEvaluationofNovelOcotillol-TypeTriterpenoidDerivativesasAntibacterialAgents.Eur.J.Med.Chem.2013,68,444-453.(IF3.499)
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